Our vepesid etoposide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Jan 26, 2020 some side effects of etoposide may occur that usually do not need medical attention. Capitals indicate lifethreatening, underlines indicate most frequent. Etoposide capsules etoposide dose, indications, adverse. Carboplatinetoposide name of proposed course of treatment include brief explanation if medical term not clear. Nov 09, 2018 etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Each of the side effects above was reported in 20% or greater of patients treated with etoposide.
Etopophos etoposide phosphate, also commonly known as vp16, is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat cancer of. Important things to remember about the side effects of etoposide. Or carboplatin and etoposide are given intravenously. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. If these drugs are used together, closely monitor for increased side. Etoposide oral chemotherapy education page 3 side effects of etoposide the common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the left side of this table. Etoposide can be administered either as intravenous infusion or in oral form. Vepesid, vp16 y etoposide eetopawside is a drug that is used to treat many types of cancers.
If you are also having treatment with other cancer drugs, you may have some side effects that we have not listed here. The most prominent side effects were myelosuppression and gi toxicity. Adverse effectsfor full details consult product literature reference texts serious side effects myelosuppression neuropathy hypersensitivity reactions nephrotoxicity. Nov 09, 2018 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Feasibility of intraventricular administration of etoposide. The information on this website is intended for informational purposes only and is not a substitute for medical advice. In clinical studies, the most commonly reported carboplatin plus etoposide drug side effects are shown here. Always consult your healthcare provider if you have questions or concerns. Warnings and precautions severe bone marrow depression this drug may raise your risk of getting a second cancer, such as leukemia low blood pressure with rapid infusion of the medication. These side effects may go away during treatment as your body adjusts to the medicine. Etoposide is a chemotherapeutic agent, widely used for the treatment of various malignancies, including small cell lung cancer sclc, an aggressive disease with poor prognosis. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects of the oral form. You may get some of the side effects we mention, but you are unlikely to get all of them.
In other words, high doses may produce more severe side effects. How carboplatin and etoposide are given you will be given carboplatin and etoposide in the. Always tell your doctor, nurse or pharmacist about any side effects you have. Possible side effects of cisplatin, etoposide table version date. Apr 10, 2018 talk to your care provider or dentist before any scheduled procedures. Etopophos etoposide injection chemotherapy, side effects. Oral etoposide childrens cancer and leukaemia group. It is used to treat small cell lung cancer and other cancers.
Vepesid, vp16 about this drug etoposide is used to treat cancer. Carboplatin and etoposide macmillan cancer support. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online web or by phone 18003321088. After treatment with etoposide has ended, normal hair growth should return. May 21, 2019 our etopophos etoposide phosphate side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Etoposide side effects, dosage, interactions drugs. Oct 01, 2019 for parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible side effect of rapid intravenous injection. Breastfeeding should be discontinued as etoposide is excreted in human milk. Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Etoposide can cause fetal harm when administered to a pregnant woman. Adverse effects for full details consult product literature reference texts serious side effects myelosuppression neuropathy hypersensitivity reactions nephrotoxicity frequently occurring side effects myelosuppression alopecia nausea and vomiting electrolyte disturbances other side effects rash. This is not a complete list of side effects and others may occur. It may be used before you get a stem cell transplant.
Some side effects of etoposide may occur that usually do not need medical attention. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate. Vepesid etoposide chemotherapy, side effects navigating care. Etoposide is a chemotherapy agent that stops the growth of cancer cells in your body. The side effects listed in this teaching sheet may not be the same ones you experience. Possible side effects more common nausea and throwing up vomiting. Etopophos, innetoposide phosphate european medicines agency. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different dose. Etoposide side effects, dosage, interactions drugs everyday health search. Advise females of potential risk to the fetus and to use effective contraception during treatment with etopophos monthsand for 6 after final dose. Find patient medical information for etoposide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Side effects are often predictable in terms of their onset and duration.
Page 1 of 5 patient agreement to systemic anticancer therapy. Toposar etoposide dose, indications, adverse effects. This includes any possible side effects not listed in this leaflet. Other side effects not listed may also occur in some patients. In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have. Options to help manage any side effects that do occur are included on the right side of this table. Etoposide phosphate side effects, dosage, interactions. Etoposide, vp16 is a substrate for the drug transporter pglycoprotein pgp. Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Call your doctor for medical advice about side effects. Etoposide can be administered either as intravenous infusion. How carboplatin and etoposide are given you will be given carboplatin and etoposide in the chemotherapy day unit or during a short stay in hospital. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. Etoposide is given as an injection into your vein over 2 to 4 hours.
As the systemic administration of etoposide is effective in the treatment of relapsed and metastatic brain tumours, a pilot trial was designed to study the feasibility of intraventricular administration of etoposide in such patients. Side effects of etopophos etoposide phosphate, warnings, uses. As the systemic administration of etoposide is effective in the treatment of relapsed and metastatic brain tumours, a pilot trial was designed to study the feasibility of intraventricular administration of. Effect of etoposide on the pharmacokinetics of other drugs. In a multidrug regimen, each medication has unique side effects. Oral treatment with etoposide in small cell lung cancer. Etoposide oral vepesid side effects, medical uses, and. It can also be given orally once daily or in divided doses in the form of a capsule. Etoposide solution for injection is indicated for the firstline. The side effects of etoposide and their severity depend on how much of the drug is given. Consumer information about the medication etoposide oral vepesid, includes side effects, drug interactions, recommended dosages, and storage information. Side effects that you should report to your doctor or health care professional as soon as possible. The side effects listed below will not affect everyone who is given etoposide and may be different if more than one chemotherapy drug is given. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were attributed to the large volumes of ns used as the diluent for administration of the drug.
Other side effects experienced with vepesid and associated names that are. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Etoposide solution for injection is to be administered slowly at a dosage of 50100 mgm 2 on days 1 to 5 every 3 or 4 weeks or 100 mgm 2 on days 1, 3 and 5 every 3 or 4 weeks. However, there are at least two case reports of hypersensitivity reactions with an alternative formulation of etoposide, etoposide phosphate, which. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were attributed to the. Major monitor for an increased incidence of etoposiderelated adverse effects if used concomitantly with grapefruit juice. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to expect. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online or by phone 18003321088. For parenteral administration, etoposide injection usp should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a. For parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible side effect of rapid intravenous injection.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. If you experience a serious side effect, you or your doctor may send a report to the. Infection, especially when white blood cell count is low. Your side effects may be different, depending on how often you receive treatment your schedule and how much you receive each time your dosage. Carboplatin and etoposide chemotherapy for the treatment of small cell lung cancer sclc thymoma. These symptoms may happen within one to six hours after getting this drug. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. The common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the. The above information includes some, but not necessarily all, of the possible side effects of this medication. Etoposide solution for injection is indicated for the first line.
You may report side effects to the fda at 1800fda1088. Etoposide intravenous route side effects mayo clinic. Read more about the prescription drug etoposide oral. Etoposide fda prescribing information, side effects and uses. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you notice any other effects, check with your healthcare professional. Side effects of etopophos etoposide phosphate, warnings. The use of etoposide requires an experienced clinician knowledgeable in administering chemotherapy. Advise males to use effective contraception for 4 months, after the last dose of etopophos. Etoposide toposar, vepesid, vp16 upmc hillman cancer.
Call your doctor if you have any unusual problems while taking this medication. The predominant macromolecular effect of etoposide appears to be the induction. Grapefruit juice is a strong inhibitor of cyp3a4 as well as a p. Find information about common, infrequent and rare side effects of etoposide oral. Etoposide oral chemotherapy education page 3 side effects of etoposide the common side effects that have. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different dose schedules for treatment of a wide variety of malignancies. Talk to your care provider or dentist before any scheduled procedures. Etoposide is an inhibitor of the enzyme topoisomerase ii, derived from podophyllum peltatum, the mayapple, a perennial herbaceous plant. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to. Etoposide 20mgml concentrate for solution for infusion etoposide.
340 1024 1452 339 1522 569 1474 690 619 236 1136 850 260 260 759 76 1160 1344 397 1387 1309 964 568 1220 1300 847 21 653 841 641 223 422 582 1341 1083 327 356 487 1297 269 516 602 185